Our driving mission at Propagenix is to create innovative cellular technologies that enable the production and delivery of the next generation of tissue therapeutics. Our particular focus is to provide best-in-class and proprietary cell bioproduction platforms for biopharma companies working on regenerative medicine involving epithelial barrier tissues. Our commitment to this focus is fueled by the needs of patients who suffer from the many varied diseases involving epithelial barrier tissue dysfunction and injury. Our work is carried out through both internal development and strategic partnerships that share our mission and have complementary capabilities.
Epithelial barrier tissues – the most common cell types in our bodies – are also those that are most important in protecting us from the external environment, regulate access to nutrients and oxygen, and provide segregation of waste products. Yet the inability to generate faithful primary epithelial cells of various types has limited biomedicine’s ability to make use of these tissues in this new age of regenerative medicine. Our technologies are specific geared to address this longstanding technical challenge: to dramatically shift the cell senescence constraints in a manner that preserves genomic integrity and functional state in the cells – all without the introduction of genetic elements or any irreversible alterations to the cell. Both normal and diseased (including many solid epithelial tumor cells) can be expanded to unprecedented levels using our platform, which has been demonstrated in over 50 external laboratories including industrial partners.
We currently focus on the expansion and differentiation of tissues from two of the most critical organs of the body—the skin and the airway. We are preparing bilayered autologous skin constructs that can be transplanted onto patients with inherited skin diseases as well as for repair of skin that has been injured or has chronic wounds. Cells lining the airway represent the second current focus area. They can be damaged or destroyed by infection, disease or injury. We are endeavoring to provide novel technical solutions for these significant healthcare problems.